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1

Studies toward the discovery of the next generation of antidepressants. Part 6: Dual 5-HT1A receptor and serotonin transporter affinity within a class of arylpiperazinyl-cyclohexyl indole derivatives

Dahui Zhou, Ping Zhou, Deborah A. Evrard, Kristin Meagher, Michael Webb, Boyd L. Harrison, Donna M. Huryn, Jeannette Golembieski, Geoffrey A. Hornby, Lee E. Schechter, Deborah L. Smith, Terrance H. An

Journal:

Bioorganic & Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 347 KB

english, 2008

2

Select pyrimidinones inhibit the propagation of the malarial parasite, Plasmodium falciparum

Annette N. Chiang, Juan-Carlos Valderramos, Raghavan Balachandran, Raj J. Chovatiya, Brian P. Mead, Corinne Schneider, Samantha L. Bell, Michael G. Klein, Donna M. Huryn, Xiaojiang S. Chen, Billy W. D

Journal:

Bioorganic & Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 279 KB

english, 2009

3

AIDS-driven nucleoside chemistry.

Huryn, Donna M., Okabe, Masami

Journal:

Chemical Reviews

Year:

1992

Language:

english

File:

PDF, 3.05 MB

english, 1992

4

Cancer Drug Design and Discovery || Natural Product Chemistry and Cancer Drug Discovery

Huryn, Donna M.

Year:

2014

Language:

english

File:

PDF, 2.46 MB

english, 2014

5

4-(2-Aminoethoxy)-N-(phenylsulfonyl)indoles as Novel 5-HT6 Receptor Ligands.

Ping Zhou, Yinfa Yan, Ronald Bernotas, Boyd L. Harrison, Donna Huryn, Albert J. Robichaud, Guo Ming Zhang, Deborah L. Smith, Lee E. Schechter

Journal:

Year:

2005

File:

PDF, 19 KB

2005

6

Experimental design on single-time-point high-throughput microsomal stability assay

Li Di, Edward H. Kerns, Ning Gao, Susan Q. Li, Youping Huang, Jim L. Bourassa, Donna M. Huryn

Journal:

Journal of Pharmaceutical Sciences

Year:

2004

Language:

english

File:

PDF, 105 KB

english, 2004

7

Synthesis of E-selectin inhibitors: Use of an aryl-cyclohexyl ether as a disaccharide scaffold

Aijun Liu, Kathleen Dillon, Robert M. Campbell, Don C. Cox, Donna M. Huryn

Journal:

Tetrahedron Letters

Year:

1996

Language:

english

File:

PDF, 235 KB

english, 1996

8

Discovery of a novel series of Notch-sparing γ-secretase inhibitors

Anthony Kreft, Boyd Harrison, Suzan Aschmies, Kevin Atchison, David Casebier, Derek C. Cole, George Diamantidis, John Ellingboe, Diane Hauze, Yun Hu, Donna Huryn, Mei Jin, Dennis Kubrak, Peimin Lu, Jo

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 199 KB

english, 2008

9

Pyrimidinone-peptoid hybrid molecules with distinct effects on molecular chaperone function and cell proliferation

Christine M. Wright, Raj J. Chovatiya, Nora E. Jameson, David M. Turner, Guangyu Zhu, Stefan Werner, Donna M. Huryn, James M. Pipas, Billy W. Day, Peter Wipf, Jeffrey L. Brodsky

Journal:

Bioorganic & Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 292 KB

english, 2008

10

Synthesis and structure–activity relationship of a novel series of heterocyclic sulfonamide γ-secretase inhibitors

Jun Pu, Anthony F. Kreft, Suzan H. Aschmies, Kevin P. Atchison, Joshua Berkowitz, Thomas J. Caggiano, Micheal Chlenov, George Diamantidis, Boyd L. Harrison, Yun Hu, Donna Huryn, J. Steven Jacobsen, Me

Journal:

Bioorganic & Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 413 KB

english, 2009

11

Synthesis, characterization and evaluation of pro-drugs of VLA-4 antagonists

Donna M Huryn, Susan Ashwell, Reinhardt Baudy, Darren B Dressen, William Gallaway, Francine S Grant, Andrei Konradi, Robert W Ley, Susan Petusky, Michael A Pleiss, Dimitri Sarantakis, Christopher M Se

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 152 KB

english, 2004

12

4-(2-Aminoethoxy)-N-(phenylsulfonyl)indoles as novel 5-HT6 receptor ligands

Ping Zhou, Yinfa Yan, Ronald Bernotas, Boyd L. Harrison, Donna Huryn, Albert J. Robichaud, Guo Ming Zhang, Deborah L. Smith, Lee E. Schechter

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 108 KB

english, 2005

13

Molecular-modeling based design, synthesis, and activity of substituted piperidines as γ-secretase inhibitors

Eric Gundersen, Kristi Fan, Kimberly Haas, Donna Huryn, J. Steven Jacobsen, Anthony Kreft, Robert Martone, Scott Mayer, June Sonnenberg-Reines, Shaiu-Ching Sun, Hua Zhou

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 185 KB

english, 2005

14

Paclitaxel C-10 carbamates: Potential candidates for the treatment of neurodegenerative tauopathies

Carlo Ballatore, Edward Hyde, Robert F. Deiches, Virginia M.-Y. Lee, John Q. Trojanowski, Donna Huryn, Amos B. Smith III

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 200 KB

english, 2007

15

Identification and characterization of 3-substituted pyrazolyl esters as alternate substrates for cathepsin B: The confounding effects of DTT and cysteine in biological assays

Michael C. Myers, Andrew D. Napper, Nuzhat Motlekar, Parag P. Shah, Chun-Hao Chiu, Mary Pat Beavers, Scott L. Diamond, Donna M. Huryn, Amos B. Smith III

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 233 KB

english, 2007

16

Identification and synthesis of a unique thiocarbazate cathepsin L inhibitor

Michael C. Myers, Parag P. Shah, Scott L. Diamond, Donna M. Huryn, Amos B. Smith III

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 148 KB

english, 2008

17

Design, synthesis, and evaluation of inhibitors of cathepsin L: Exploiting a unique thiocarbazate chemotype

Michael C. Myers, Parag P. Shah, Mary Pat Beavers, Andrew D. Napper, Scott L. Diamond, Amos B. Smith III, Donna M. Huryn

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 229 KB

english, 2008

18

Synthesis of iso-ddA, member of a novel class of anti-HIV agents

Donna M. Huryn, Barbara C. Sluboski, Steve Y. Tam, Louis J. Todaro, Manfred Weigele

Journal:

Tetrahedron Letters

Year:

1989

Language:

english

File:

PDF, 162 KB

english, 1989

19

Pharmaceutical profiling method for lipophilicity and integrity using liquid chromatography–mass spectrometry

Edward H. Kerns, Li Di, Susan Petusky, Teresa Kleintop, Donna Huryn, Oliver McConnell, Guy Carter

Journal:

Journal of Chromatography B

Year:

2003

Language:

english

File:

PDF, 363 KB

english, 2003

20

Total synthesis of (+)-mikrolin

Amos B. Smith III, Yasushi Yokoyama, Donna M. Huryn, Norma K. Dunlap

Journal:

Tetrahedron Letters

Year:

1987

Language:

english

File:

PDF, 249 KB

english, 1987

21

Synthesis and Biological Activity of a Focused Library of Mitogen-activated Protein Kinase Phosphatase Inhibitors

David M. Arnold, Caleb Foster, Donna M. Huryn, John S. Lazo, Paul A. Johnston, Peter Wipf

Journal:

Chemical Biology & Drug Design

Year:

2007

Language:

english

File:

PDF, 212 KB

english, 2007

22

Identification and Characterization of Small Molecule Antagonists of pRb Inactivation by Viral Oncoproteins

Daniela Fera, David C. Schultz, Santosh Hodawadekar, Melvin Reichman, Preston Scott Donover, Jason Melvin, Scott Troutman, Joseph L. Kissil, Donna M. Huryn, Ronen Marmorstein

Journal:

Chemistry & Biology

Year:

2012

Language:

english

File:

PDF, 1.17 MB

english, 2012

23

Microtubule Stabilizing Agents as Potential Treatment for Alzheimer’s Disease and Related Neurodegenerative Tauopathies

Ballatore, Carlo, Brunden, Kurt R., Huryn, Donna M., Trojanowski, John Q., Lee, Virginia M.-Y., Smith, Amos B.

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 2.55 MB

english, 2012

24

Identification of Aminothienopyridazine Inhibitors of Tau Assembly by Quantitative High-Throughput Screening

Crowe, Alex, Huang, Wenwei, Ballatore, Carlo, Johnson, Ronald L., Hogan, Anne-Marie L., Huang, Ruili, Wichterman, Jennifer, McCoy, Joshua, Huryn, Donna, Auld, Douglas S.

Journal:

Year:

2009

Language:

english

File:

PDF, 2.35 MB

english, 2009

25

Cancer Drug Design and Discovery Volume 83 || Natural product chemistry and anticancer drug discovery

Huryn, Donna M.

Year:

2008

Language:

english

File:

PDF, 510 KB

english, 2008

26

Screening of 5-HT 1A Receptor Antagonists using Molecularly Imprinted Polymers

O'Connor, Naphtali A., Paisner, David A., Huryn, Donna, Shea, Kenneth J.

Journal:

Journal of the American Chemical Society

Year:

2007

Language:

english

File:

PDF, 5.21 MB

english, 2007

27

Comprehensive Organic Synthesis || Carbanions of Alkali and Alkaline Earth Cations: (ii) Selectivity of Carbonyl Addition Reactions

Huryn, Donna M.

Year:

1991

Language:

english

File:

PDF, 2.98 MB

english, 1991

28

Molecular Docking of Cathepsin L Inhibitors in the Binding Site of Papain

Beavers, Mary Pat, Myers, Michael C., Shah, Parag P., Purvis, Jeremy E., Diamond, Scott L., Cooperman, Barry S., Huryn, Donna M., Smith, Amos B.

Journal:

Journal of Chemical Information and Modeling

Year:

2008

Language:

english

File:

PDF, 2.26 MB

english, 2008

29

Anabolism and Mechanism of Action of Ro24-5098, an Isomer of 2′,3′-Dideoxyadenosine (ddA) with Anti-HIV Activity

KARL B. FRANK, EDWARD V. CONNELL, MICHAEL J. HOLMAN, DONNA M. HURYN, BARBARA C. SLUBOSKI, STEVE Y. TAM, LOUIS J. TODARO, MANFRED WEIGELE, DOUGLAS D. RICHMAN, HIROAKI MITSUYA, SAMUEL BRODER, IAIN S. SI

Journal:

Annals of the New York Academy of Sciences

Year:

1990

Language:

english

File:

PDF, 297 KB

english, 1990

30

Carboxylic Acid (Bio)Isosteres in Drug Design

Ballatore, Carlo, Huryn, Donna M., Smith, Amos B.

Journal:

Year:

2013

Language:

english

File:

PDF, 482 KB

english, 2013

31

Drug Discovery in an Academic Setting: Playing to the Strengths

Huryn, Donna M.

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 149 KB

english, 2013

32

Microtubule-stabilising drugs for therapy of Alzheimer’s disease and other neurodegenerative disorders with axonal transport impairments

Trojanowski, John Q, Smith, Amos B, Huryn, Donna, Lee, Virginia M-Y

Journal:

Expert Opinion on Pharmacotherapy

Year:

2005

Language:

english

File:

PDF, 66 KB

english, 2005

33

Cyclopentane-1,3-dione: A Novel Isostere for the Carboxylic Acid Functional Group. Application to the Design of Potent Thromboxane (A2) Receptor Antagonists

Ballatore, Carlo, Soper, James H., Piscitelli, Francesco, James, Michael, Huang, Longchuan, Atasoylu, Onur, Huryn, Donna M., Trojanowski, John Q., Lee, Virginia M.-Y., Brunden, Kurt R., Smith, Amos B.

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 3.38 MB

english, 2011

34

Contributions of Academic Laboratories to the Discovery and Development of Chemical Biology Tools

Huryn, Donna M., Resnick, Lynn O., Wipf, Peter

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 2.19 MB

english, 2013

35

A New Synthesis of 4,5,6,7-Tetrahydropyrazolo[1,5-c]pyrimidines by a Retro-Mannich Cascade Rearrangement

Colombo, Raffaele, Jeon, Kyu Ok, Huryn, Donna M., LaPorte, Matthew G., Wipf, Peter

Journal:

Australian Journal of Chemistry

Year:

2014

Language:

english

File:

PDF, 1.32 MB

english, 2014

36

Appointments

Harrison, Boyd L., Kreft, Anthony, Aschmies, Susan, Atchison, Kevin, Cole, Derek, Ellingboe, John, Hauze, Diane, Hu, Yun, Huryn, Donna, Jin, Mei, Kubrak, Dennis, Lu, Peimin, Mann, Charles, Martone, Ro

Journal:

Year:

1941

Language:

english

File:

PDF, 236 KB

english, 1941

37

P4-244

Harrison, Boyd L., Kreft, Anthony, Aschmies, Susan, Atchison, Kevin, Cole, Derek, Ellingboe, John, Hauze, Diane, Hu, Yun, Huryn, Donna, Jin, Mei, Kubrak, Dennis, Lu, Peimin, Mann, Charles, Martone, Ro

Journal:

Alzheimer's & Dementia

Year:

2006

Language:

english

File:

PDF, 92 KB

english, 2006

38

Synthesis and Biological Evaluation of Benzodioxanylpiperazine Derivatives as Potent Serotonin 5-HT 1A Antagonists: The Discovery of Lecozotan

Childers,, Wayne E., Abou-Gharbia, Magid A., Kelly, Michael G., Andree, Terrance H., Harrison, Boyd L., Ho, Douglas M., Hornby, Geoffrey, Huryn, Donna M., Potestio, Lisa, Rosenzweig-Lipson, Sharon J.,

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 123 KB

english, 2005

39

Total synthesis of (-)-gilmicolin

Smith, Amos B., Huryn, Donna M.

Journal:

Journal of Organic Chemistry

Year:

1985

Language:

english

File:

PDF, 378 KB

english, 1985

40

2-Guanidinoquinazolines as new inhibitors of the STAT3 pathway

LaPorte, Matthew G., da Paz Lima, Dimas José, Zhang, Feng, Sen, Malabika, Grandis, Jennifer R., Camarco, Daniel, Hua, Yun, Johnston, Paul A., Lazo, John S., Resnick, Lynn O., Wipf, Peter, Huryn, Donna

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.43 MB

english, 2014

41

[Annual Reports in Medicinal Chemistry] Annual Reports in Medicinal Chemistry Volume 42 Volume 42 || Chapter 26 The Molecular Libraries Screening Center Network (MLSCN): Identifying Chemical Probes of Biological Systems

Huryn, Donna M.

Year:

2007

Language:

english

File:

PDF, 149 KB

english, 2007

42

Molecular Docking of Cathepsin L Inhibitors in the Binding Site of Papain

Beavers, Mary Pat, Myers, Michael C., Shah, Parag P., Purvis, Jeremy E., Diamond, Scott L., Cooperman, Barry S., Huryn, Donna M., Smith, Amos B.

Journal:

Journal of Chemical Information and Modeling

Year:

2010

File:

PDF, 18 KB

2010

43

Synthesis and Biological Evaluation of Novel Compounds within a Class of 3-Aminochroman Derivatives with Dual 5-HT 1A Receptor and Serotonin Transporter Affinity

Hatzenbuhler, Nicole T., Evrard, Deborah A., Harrison, Boyd L., Huryn, Donna, Inghrim, Jennifer, Kraml, Christina, Mattes, James F., Mewshaw, Richard E., Zhou, Dahui, Hornby, Geoffrey, Lin, Qian, Smit

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 83 KB

english, 2006

44

Synthesis and anti-HIV activity of isonucleosides

Huryn, Donna M., Sluboski, Barbara C., Tam, Steve Y., Weigele, Manfred, Sim, Iain, Anderson, Barry D., Mitsuya, Hiroaki, Broder, Samuel

Journal:

Journal of Medicinal Chemistry

Year:

1992

Language:

english

File:

PDF, 1.11 MB

english, 1992

45

Synthesis of the 6′-Fluoro Derivatives of Carbocyclic 2′,3′-Dideoxy-3′-oxa-adenosine

Tam, Steve, Holman, Michael, Huryn, Donna, Cislo, Andrew

Journal:

Nucleosides and Nucleotides

Year:

1991

Language:

english

File:

PDF, 188 KB

english, 1991

46

HTS Identifies Novel and Specific Uncompetitive Inhibitors of the Two-Component NS2B-NS3 Proteinase of West Nile Virus

Johnston, Paul A., Phillips, Jennifer, Shun, Tong Ying, Shinde, Sunita, Lazo, John S., Huryn, Donna M., Myers, Michael C., Ratnikov, Boris I., Smith, Jeffrey W., Su, Ying, Dahl, Russell, Cosford, Nich

Journal:

Assay and Drug Development Technologies

Year:

2007

Language:

english

File:

PDF, 309 KB

english, 2007

47

Our Scope Expansion to Include Biologics

Maryanoff, Bruce E., Huryn, Donna M.

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 121 KB

english, 2015

48

A Focused Library of Tetrahydropyrimidinone Amides via a Tandem Biginelli-Ugi Multi-Component Process

Werner, Stefan, Turner, David, Lyon, Michael, Huryn, Donna, Wipf, Peter

Journal:

Year:

2006

Language:

english

File:

PDF, 79 KB

english, 2006

49

Editorial [Hot topic: Medicinal Chemistry in the Pilot Phase of the Molecular Libraries Screening Center Network (Guest Editor: Donna M. Huryn)]

Journal:

Current Topics in Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 15 KB

english, 2009

50

HCS Campaign to Identify Selective Inhibitors of IL-6-Induced STAT3 Pathway Activation in Head and Neck Cancer Cell Lines

Johnston, Paul A., Sen, Malabika, Hua, Yun, Camarco, Daniel P., Shun, Tong Ying, Lazo, John S., Wilson, Gabriela Mustata, Resnick, Lynn O., LaPorte, Matthew G., Wipf, Peter, Huryn, Donna M., Grandis,

Journal:

Assay and Drug Development Technologies

Year:

2015

Language:

english

File:

PDF, 1.24 MB

english, 2015